Although not related in blood he appears to have inherited the estates in Lincolnshire of the Kyme family, and he was generally known as the earl of Kyme, though the title was never properly conferred upon him.
Her elder sister, Martha, was betrothed by her parents to Thomas Kyme, a Lincolnshire justice of the peace, but she died before marriage, and Anne was induced or compelled to take her place.
She is said to have had two children by Kyme, but religious differences and incompatibility of temperament soon estranged the couple.
Kyme was apparently an unimaginative man of the world, while Anne took to Biblereading with zeal, became convinced of the falsity of the doctrine of transubstantiation, and created some stir in Lincoln by her disputations.
According to Bale and Foxe her husband turned her out of doors, but in the privy council register she is said to have "refused Kyme to be her husband without any honest allegation."
Kyme was sent home into Lincolnshire, but Anne was committed to Newgate, "for that she was very obstinate and heady in reasoning of matters of religion."