When taken internally it is both a secretory and an excretory cholagogue, but so irritant and powerful that its use in cases of jaundice is generally undesirable.
A fever that is to be remittent will usually declare itself from the outset: it begins with chills, but without the shivering and shaking fit of the intermittent; the hot stage soon follows, presenting the same characters as the prolonged hot stage of the quotidian, with the frequent addition of bilious symptoms, and it may be even of jaundice and of tenderness over the stomach and liver.
Remittent fevers (as well as intermittents) vary considerably in intensity; some cases are intense from the outset, or pernicious, with aggrava tion of all the symptoms - leading to stupor, delirium, collapse, intense jaundice, blood in the stools, blood and albumen in the urine, and, it may be, suppression of urine followed by convulsions.
In hepatogenous pigmentation (icterus or jaundice) we have the iron-free pigment modified and transformed by the action of the liver cells into bile pigment (bilirubin).
Thus it came about not only that classifications of disease based on superficial likeness - such as jaundice, dropsy, inflammation - were broken up, and their parts redistributed, but also that even more set diseases began to lose their settlements, and were recognized as terms of series, as transitory or culminating phases of perturbations which might be traced to their origins, and in their earlier stages perhaps withstood.
Of such are the better understanding of the functions of the liver in normal catabolism, in the neutralization of poisons absorbed from the intestines or elsewhere, in the causation of jaundice, and in diabetes [Bernhardt Naunyn (b.
Peltigera canin g, which formed the basis of the celebrated " pulvis antilyssus " of Dr Mead, long regarded as a sovereign cure for hydrophobia; Platysma juniperinum, lauded as a specific in jaundice, no doubt on the similia similibus principle from a resemblance between its yellow colour and that of the jaundiced skin; Peltidea aphthosa, which on the same principle was regarded by the Swedes, when boiled in milk, as an effectual remedy for the aphthae or rash on their children.
White Sulphur Springs, in Greenbrier county, impregnated with sulphur, with therapeutic application in jaundice, dyspepsia, &c.; Alleghany Springs, in Montgomery (disambiguation)|Montgomery county, calcareous and earthy, purgative and diuretic; Rawley Springs in Rockingham county, Sweet Chalybeate Springs in Alleghany county, and Rockbridge Alum Springs in Rockbridge county, classed as iron springs and reputed of value as tonics, and the thermal springs, Healing Springs (88° F.) and Hot Springs (Iio F.), both in Bath (disambiguation)|Bath county are noted medicinal springs.
Amongst other places having a similar action are Marienbad, Franzensbad and Tarasp. The waters just mentioned contain free alkali as well as sulphates, and are employed more especially in cases of hepatic disorder, such as congestion of the liver, jaundice, gall-stone and diabetes.