The salt is a corrosive irritant poison when taken internally.
When salicin is taken internally no irritant action occurs, nor is there any antisepsis.
It possesses the advantage of exercising but little irritant effect upon the bowels.
Colchicum or colchicine, when applied to the skin, acts as a powerful irritant, causing local pain and congestion.
The permanganate of potash is an irritant if used pure.
Cantharides is used externally for its counter-irritant action.
The term counterirritant is used when an irritant is applied to the skin for the purpose of relieving pain or congestion by dilating the superficial vessels.
Salicylic acid is a powerful irritant when inhaled or swallowed in a concentrated form, and even when much diluted it causes pain, nausea and vomiting.
Thoroughly rubbed into the skin alcohol dilates the bloodvessels and produces a mild counter-irritant effect.
- Sulphur itself has no action, but when brought into contact with the secretions it forms sulphides, sulphites and sulphuretted hydrogen, and thereby becomes more or less irritant and antiseptic. In the bowel its conversion into sulphides causes it to act as a mild laxative.
On a mucous membrane or a delicate skin it exerts an irritant action, which occurs more quickly than on a thickened epidermis, such as the scalp, and according to the strength and period of application there may result redness, a blister, or an ulcer.
The irritant may be chemical, as is seen in the skin cancers that develop in workers in paraffin, petroleum, arsenic and aniline.
For inflammation of the mouth a similar combination is used as a mouth wash, in the throat as a gargle, and in the nose as a wash and sometimes as an ointment or spray, the ointment possessing the advantage of protecting the delicate nasal mucous membrane from irritation by stopping the entrance of irritant dust into the nasal cavities.
By preventing fermentation in the intestine these also tend to prevent or check diarrhoea, and they may do good after the irritant has been removed by castor oil.
After the irritant has been removed and fermentation stopped, the irritation still remaining in the intestinal wall may be soothed by chalk mixture and bismuth, to which if necessary small quantities of opium may be added.
Given in toxic doses or in strong solution, sulphuric acid is a severe gastro-intestinal irritant, causing intense burning pain, extending from the mouth to the stomach, and vomiting of mucous and coffee-coloured material.
It acts as a rubefacient, an irritant and a counter-irritant.
It must not be used to check haemorrhage from the kidneys (haematuria) owing to its irritant action on those organs, but in haemoptysis (haemorrhage from the lungs) it is often an invaluable remedy.
If it be absorbed from a surgical dressing there are no irritant symptoms, but when the acid is swallowed in concentrated form, symptoms of gastro-intestinal irritation occur.
In larger doses colchicum or colchicine acts as a most violent gastrointestinal irritant, causing terrible pain, colic,vomiting, diarrhoea, haemorrhage from the bowel, thirst and ultimately death from collapse.
Though ammonium chloride has certain irritant properties which may disorder the stomach, yet if its mucous membrane be depressed and atonic the drug may improve its condition, and it has been used with success in gastric and intestinal catarrhs of a subacute type and is given in doses of io grains half an hour before meals in painful dyspepsia due to hyperacidity.
Recent work has shown it is too feeble to be relied upon alone, but where really efficient antiseptics, such as mercuric chloride and iodide, and carbolic acid, have been already employed, boracic acid (which, unlike these, is non-poisonous and non-irritant) may legitimately be used to maintain the aseptic or non-bacterial condition which they have obtained.
The British Pharmacopoeia contains a watery solution - the Aqua Chloroformi - which is useful in disguising the taste of nauseous drugs; a liniment which consists of equal parts of camphor liniment and chloroform, and is a useful counter-irritant; the Spiritus Chloroformi (erroneously known as "chloric ether"), which is a useful anodyne in doses of from five to forty drops; and the Tinctura Chloroformi et Morphinae Composita, which is the equivalent of a proprietary drug called chlorodyne.
The uses of chloroform which fall to be mentioned here are: - as a counter-irritant; as a local anaesthetic for toothache due to caries, it being applied on a cotton wool plug which is inserted into the carious cavity; as an antispasmodic in tetanus and hydrophobia; and as the best and most immediate and effective antidote in cases of strychnine poisoning.
Thus irritation of the eye causes winking and secretion of tears, by which the irritant is removed; irritation of the nose causes sneezing; of the air-passages, coughing; of the stomach, vomiting; and of the intestines, diarrhoea.
Quinine does not affect the unbroken skin, and cannot be absorbed from it, but it is slightly irritant to the pain-conducting nerves of a raw surface.
The hypophosphites have been recommended in pulmonary affections, being said to act as free phosphorus without being irritant, and the glycero-phosphates are certainly useful to stimulate metabolism.
For external use, sulphuric acid is a powerful irritant and caustic, acting by its powerful affinity for water and therefore dehydrating the tissues and causing them to turn black.
Their soluble salts combine with albumen and preserve it, strong solutions being extremely irritant or caustic, while weaker ones are astringent simply, or even soothing.
When taken internally it is both a secretory and an excretory cholagogue, but so irritant and powerful that its use in cases of jaundice is generally undesirable.
Externally: Caustic potash is a most powerful irritant and caustic; it is used with lime in making Vienna paste, which is occasionally used to destroy morbid growths.
The condition which remains after the irritant has been removed is one of inflammation more or less intense.
In some abdominal conditions, for instance, opium is still preferred by the majority of practitioners, though certainly not in gastric cases, where morphine gives the relief for which opium often increases the need, owing to the irritant action of some of its constituents.
Mercury and lead are absorbed from the bowel in considerable quantities, and are capable of inducing acute irritant poisoning as well as chronic poisoning.
After the irritant has been removed either from the stomach or intestine, a feeling of irritation of the mucous membrane may remain, and sickness, diarrhoea or pain may continue in the stomach and intestine although the irritant is no longer present within them, just as the flow of tears and desire to rub may remain in the eye after the piece of grit which has occasioned it may have been removed.
When taken by the mouth phosphorus is an irritant poison in large doses; in small doses the only effects noticeable consist in an increased formation of bony and connective tissue, although it is also supposed to exert a gently stimulating effect upon the nervous system.
The drug is described as a counter-irritant, though the explanation of this action is very doubtful.
- Although some of the drugs already considered have a local irritant action, they produce other more important effects, but the substances here ranged under this heading depend entirely for their action on their local irritant effects.
Summed up, its action is that of an irritant, and a cardiac and nervous depressant.
Locally they are all three strongly irritant or caustic, owing to their chemical action on albumen.