Chronic opium poisoning by the taking of laudanum - as in the familiar case of De Quincey - need not be considered here, as the hypodermic injection of morphine has almost entirely supplanted it.
Of the numerous preparations only two need be mentioned - the liquid extract (dose 10 minims to 2 drachms or more), and the hypodermic injection.
A recent method of using the drug is in the form of sodium cacodylate by subcutaneous injection, and this preparation is said to be free from the cumulative effects sometimes arising after the prolonged use of the other forms. Other organic derivatives employed are sodium metharsenite and sodium anilarsenate or atoxyl; hypodermic injections of the latter have been used in the treatment of sleeping sickness.
The most frequent mode of administration is the hypodermic method, on account of the extreme rapidity with which it is absorbed.
Hypodermic injection of strychnine, in some cases as much as one to two grains (but not into a vein!), has in some cases had good results; but injection of ammonia, instead of doing any good, has disastrous sloughing results.