Vezhdovsky has lately seen reasons for regarding the blood system as originating entirely from the hypoblast by the secretion of fluid, the blood, from particular intestinal cells and the consequent formation of spaces through pressure, which become lined with these cells.
The hypoblast in some forms originates by invagination, in others by delamination.
That portion of the gut which is formed by the hypoblast, whereas in Hexapod insects the similar caecal tubes are developed from the proctodaeum or in -pushed portion of the gut which is formed from epiblast.
Moreover, the body cavity of the rotifers is a primitive archicoele; the persistent or accrescent cleft between epiblast and hypoblast, traversed by mesenchymal muscular bands.
The little mass of hypoblast or enteric cell-mass now enlarges, but remains connected with the cicatrix of the blastopore or orifice of invagination by a stalk, the rectal peduncle.
The embryo now consists of two layers of cells, epiblast and hypoblast, surrounding a cavity, the archenteron, which opens to the exterior by the orifice of invagination or blastopore.
The hypoblast is formed either by a definite invagination or by the immigration of isolated cells, known as vitellophags, which wander through the yolk and later become associated into a definite mesenteron, or by some combination of these two methods.