HIPPURIC ACID (Gr.
The glands secrete hippuric acid which passes from the pericardium into the renal organs.
1868, 148, p. 51); by hydrolysis of benzonitrile or of hippuric acid; by the action of carbon dioxide on benzene in the presence of aluminium chloride (C. Friedel and J.
Lunge, Berichte, 1877, 10, p. 12 75); by fusing sodium benzene sulphonate with sodium formate: C6H5S03Na+-HC02Na=C6HS000Na+ NaHS0 3; by heating calcium phthalate with calcium hydroxide to 330 0 -350° C.; by heating benzotrichloride with water in a sealed tube, and from the hippuric acid which is found in the urine of the herbivorae.
For this purpose the urine is concentrated and the hippuric acid precipitated by the addition of hydrochloric acid; it is then filtered and boiled for some time with concentrated hydrochloric acid, when it is hydrolysed into benzoic and amido-acetic acid.
The acid itself is a powerful antiseptic. When administered internally, it causes the appearance of hippuric acid in the urine.
The hippuric acid in the urine acts as a stimulant and disinfectant to the urinary mucous membrane.
Bamberger, Ber., 94, 7, 1955), C,H 5 CH: CH CH: NOH --4[C 6 H 5 CH: CH NH COH] -*C,H,N; by the action of hydriodic acid on the oxydichlorisoquinoline formed when phosphorus pentachloride reacts with hippuric acid; by the distillation of homophthalimide over zinc dust (M.
An improved method of preparation was found in the use of hippuric acid, which reacts with hydrazine hydrate to form hippuryl hydrazine, C 6 H 5 [[Conh Ch 2 Conh Nh]] 2, and this substance is converted by nitrous acid into diazo-hippuramide, C 6 H 5 [[Conh Ch 2 Co Nh N 2.0h]], which is hydrolysed by the action of caustic alkalis with the production of salts of hydrazoic acid.