Hernan Cortes overran and conquered Mexico from 1518 to 1521, and the discovery and conquest of Guatemala by Alvarado, the invasion of Florida by De Soto, and of Nueva Granada by Quesada, followed in rapid succession.
From Cuba it was that Hernan Cortes sailed on the 10th (or 18th) of February 1519 for the conquest of Mexico.
From Santiago in1518-1519departed the historic expeditions of Juan de Grijalva, Hernan Cortes and Pamfilo de Narvaez - the last of 18 vessels and 110o men of arms, excluding sailors.
De Henares under the celebrated Hellenist, Hernan Nunez.
The conquest of Mexico by Hernan Cortes and of Peru by Francisco Spain and Pizarro (q.v.) belong to this reign, but were imme- the Eurodiately due to the adventurers in America.