The lines of cardinal importance are (I) the rasceta or cross sulci, which isolate the hand from the forearm at the wrist, and which are the flexion folds between the looser forearm skin and that tied down to the fascia above the level of the anterior annular ligament.
(2) The line which isolates the ball of the thumb, where the skin ceases to be tied to the front of the palmar fascia, is called the line of life.
For this purpose the skin is tied by connecting fibres of white fibrillar tissue to the deep layer of the dermis along the lateral and lower edges of the palmar fascia and to the sheaths of the flexor tendons.
The folds, therefore, which are disposed for the purpose of making the grasp secure, vary with the relative lengths of the metacarpal bones, with the mutual relations of the sheaths of the tendons, and the edge of the palmar fascia, somewhat also with the insertion of the palmaris brevis muscle.
In this, as in all forms of neuralgia, there are certain localities where the pain is more intense, these "painful points," as they are called, being for the most part in those places where the branches of the nerves emerge from bony canals or pierce the fascia to ramify in the skin.