It is a most important synthetic reagent; with sodium or sodium ethylate it forms sodio-malonic ester, which reacts readily with alkyl halides, forming alkyl malonic esters, which are again capable of forming sodium derivatives, that by further treatment with alkyl halides yield the di-alkyl malonic esters.
CH :CH (OH), formed by acting on formic ester with acetone in the presence of sodium ethylate, readily yields [1.3.51-triacetylbenzene, C 6 H 3 (CO CH 3) 3; oxymethylene acetic ester or formyl acetic ester or ß-oxyacrylic ester, (HO)CH :CH CO 2 C 2 H 51 formed by condensing acetic ester with formic ester, and also its dimolecular condensation product, coumalic acid, readily yields esters of [1.3.
With sodium ethylate in ethyl acetate solution it forms the sodium derivative of benzoyl acetone, from which benzoyl acetone, C6H5.CO.CH2.CO.CH3, can be obtained by acidification with acetic acid.
It is prepared by oxidizing cinnamyl alcohol, or by the action of sodium ethylate on a mixture of benzaldehyde and acetaldehyde.
The primary nitroparaffins combine with nitric oxide in the presence of sodium ethylate, to form nitroalkylisonitramines, R CH(NO 2) N 2 0 2 H (W.
The potassium salt is formed by the action of potassium ethylate on tetranitromethane (A.
00 2 H 5, is obtained in the form of pearly scales when carbon dioxide is passed into an alcoholic solution of potassium ethylate, C02+KOC2H5 = KO CO.
When it is heated to 120° C. with sodium ethylate it decomposes into ethyl ether and sodium ethyl carbonate (A.
Ortho-carbonic ester, C(0C2H5)4, is formed by the action of sodium ethylate on chlorpicrin (H.
Carbon monoxide takes part in the syntheses of sodium formate from sodium hydrate, or soda lime (at 200 0 -2 20 0), and of sodium acetate and propionate from sodium methylate and sodium ethylate at 160 0 -200°.
Sodyl hydroxide, NaHO 2, exists in two forms: one, Na O.OH, obtained from hydrogen peroxide and sodium ethylate; the other, 0 :Na OH, from absolute alcohol and sodium peroxide at 0 °.
The metal also reacts with alcohol to form potassium ethylate, while hydrogen escapes, this time without inflammation: K+C 2 H 5.
It can be prepared by the reduction of phenyl propiolic acid with zinc and acetic acid, by heating benzal malonic acid, by the condensation of ethyl acetate with benzaldehyde in the presence of sodium ethylate or by the so-called "Perkin reaction"; the latter being the method commonly employed.
It reacts with sodium ethylate to form ortho-formic ester, CH(OC 2 H 5) 3, and when heated with aqueous ammonia for some hours at 200-220° C. gives carbon monoxide and ammonium formate, 2CHC1 3 + 7N11 3 -13H 2 0= NH 4 HCO 2 + C0+6NH4C1 (G.
They also condense with aldehydes, under the influence of alkalis or sodium ethylate (L.
They form unstable addition products with sodium ethylate or methylate.
It may be prepared by the hydrolysis of ethyl acetoacetate, or by passing carbon monoxide over a mixture of sodium acetate and sodium ethylate at 205° C. (A.
C 2 H 5, is prepared from methyl iodide and sodium ethylate, or from ethyl iodide and sodium methylate (A.
It may be synthetically obtained by distilling oxindole (C 8 H 8 NO) with zinc dust; by heating orthonitrocinnamic acid with potash and iron filings; by the reduction of indigo blue; by the action of sodium ethylate on orthoaminochlorstyrene; by boiling aniline with dichloracetaldehyde; by the dry distillation of ortho-tolyloxamic acid; by heating aniline with dichioracetal; by distilling a mixture of calcium formate and calcium anilidoacetate; and by heating pyruvic acid phenyl hydrazone with anhydrous zinc chloride.
Dieckmann, Ber., 1894, 27, pp. 103, 2 475): CH 2 CH 2 CH2 CO,R CH2 CH2 CH2 CH2 CH2 C02R 7->CH2 CH2C O by the action of sodium ethylate on 3-ketonic acids (D.
Kerp, Ann., 1896, 290, p. 123): CH2 C(CH3) 3CH3 CO CH3-(CHa)2C? ??CH CH 2 COQ by the condensation of succinic acid with sodium ethylate, followed by saponification and elimination of carbon dioxide:- 2C2H4(COzH) C 2 - H2 CH 2 CO CO.
CH 2 CH 2 ' and from the condensation of ethyl oxalate with esters of other dibasic acids in presence of sodium ethylate (W.
4, which is obtained as its ester by the action of sodium or sodium ethylate on succinic ester (H.
With alcohol it forms lithium ethylate, LiOC 2 H 6, with liberation of hydrogen.
Claisen, whose views are now accepted, studied the reactions of sodium ethylate and showed that if sodium ethylate be used in place of sodium in the above reaction the same result is obtained.