The sharpless asymmetric epoxidation has been known for 20 years and
produces epoxides
from allylic alcohols with high degrees of stereocontrol.
Epoxide hydrolase.
Scheme 1 the required
cyclobutene epoxides
are prepared in a two-step sequence from the corresponding norbornene.
Epoxide ring
opening.
Targets include other aeds, particularly phenytoin, phenobarbitone,
carbamazepine epoxide, and lamotrigine.
Epoxide groups.
Epoxide metabolite
that could damage dna.
Epoxide ring opening.
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