In toxic doses podophyllin causes intense enteritis, with all its characteristic symptoms, and severe depression, which may end in death.
The now well-known fact that small doses of poisonous substances may act as stimuli to living protoplasm, and that respiratory activity and growth may be accelerated by chloroform, ether and even powerful mineral poisons, such as mercuric chloride, in minimal doses, offers some explanation of these phenomena of hypertrophy, wound fever, and other responses to the presence of irritating agents.
Taken internally, in doses of from one to three grains, carbolic acid will often relieve obstinate cases of vomiting and has some value as a gastric antiseptic.
Colchicine is the active principle and may be given in full form in doses of to 1 1 8 grain.
The British Pharmacopoeia contains (i) an extract of the fresh corm, having doses of 4 to i grain, and (2) the Vinum Colchici, made by treating the dried corm with sherry and given in doses of 10 to 30 minims. This latter is the preparation still most generally used, though the presence of veratrine both in the corm and the seeds renders the use of colchicine itself theoretically preferable.
The salicylate of colchicine is stable in water and may be given in doses of about one-thirtieth of a grain.
In larger doses colchicum or colchicine acts as a most violent gastrointestinal irritant, causing terrible pain, colic,vomiting, diarrhoea, haemorrhage from the bowel, thirst and ultimately death from collapse.
Large doses also depress the nervous system, weakening the anterior horns of grey matter in the spinal cord so as ultimately to cause complete paralysis, and also causing a partial insensibility of the cutaneous nerves of touch and pain.
A further curious fact, doubtless of very great significance, but hitherto lacking interpretation, is that the administration of colchicum during an acute attack of gout may often hasten the oncoming of the next attack; and this property, familiar to many gouty patients, may not be affected by the administration of small doses after the attack.
According to Ross, it should be given promptly, in sufficient doses (up to 30 grains), and should be continued for months.
Given by the mouth glycerin produces purging if large doses are administered, and has the same action if only a small quantity be introduced into the rectum.
Very large doses in animals cause lethargy, collapse and death.
UNICEF has said a program that gives children two large doses a year of vitamin A could all but eliminate VAD, although more frequent, smaller doses would be better.
Every day or two I strolled to the village to hear some of the gossip which is incessantly going on there, circulating either from mouth to mouth, or from newspaper to newspaper, and which, taken in homoeopathic doses, was really as refreshing in its way as the rustle of leaves and the peeping of frogs.
Their usefulness did not depend on making the patient swallow substances for the most part harmful (the harm was scarcely perceptible, as they were given in small doses), but they were useful, necessary, and indispensable because they satisfied a mental need of the invalid and of those who loved her--and that is why there are, and always will be, pseudo-healers, wise women, homeopaths, and allopaths.
Officially, at large gatherings, everyone said that Countess Bezukhova had died of a terrible attack of angina pectoris, but in intimate circles details were mentioned of how the private physician of the Queen of Spain had prescribed small doses of a certain drug to produce a certain effect; but Helene, tortured by the fact that the old count suspected her and that her husband to whom she had written (that wretched, profligate Pierre) had not replied, had suddenly taken a very large dose of the drug, and had died in agony before assistance could be rendered her.