In medicine antipyrine ("phenazonum") has been used as an analgesic and antipyretic. The dose is 5-20 grs., but on account of its depressant action on the heart, and the toxic effects to which it occasionally gives rise, it is now but little used.
The sudden withdrawal of the drug from a morphine habitué is followed by a train of alarming symptoms. As the time approaches for the usual dose there is marked restlessness, followed by excitement and later by chills, pallor, sinking, nausea, with perhaps vomiting and diarrhoea.
Casper was the last to leave the corral, pausing beside Carmen for an extra dose of attention.
The volatile oil - oleum cubebae - is also official, and is the form in which this drug is most commonly used, the dose being 5 to 20 minims, which may be suspended in mucilage or given after meals in a cachet.
The pharmacopeial dose of the acid is 5-20 grains, but it is so unrelated to experience and practice that it may be ignored.
The symptoms of strychnine poisoning usually appear within twenty minutes of the ingestion of a poisonous dose, starting with an uneasy sensation, stiffness at the back of the neck, twitching of the muscles and a feeling of impending suffocation.
After the taking of a moderate dose the pulse is markedly slowed.
We played back our conversation with crossed fingers and not a small dose of nervousness.
The new canine member of our family was a happy little feller with a fair dose of Cocker Spaniel in his genealogy.
An IV in her arm dripped a constant dose of powerful anesthetic.
Potassii Citras, dose To to 40 grs.
It is by no means the most powerful poison known, for such an alkaloid as pseud-aconitine, which is lethal in dose of about 1/200 of a grain, is some hundreds of times more toxic, but prussic acid is by far the most rapid poison known, a single inhalation of it producing absolutely instantaneous death.
For the destruction of weeds on gravel walks or in paved yards a strong dose of salt, applied either dry or in a very strong solution, is found very effective, especially a hot solution, but after a time much of it becomes washed down, and the residue acts as a manure; its continued application is undesirable, as gravel so treated becomes pasty.
Cynthia, who'd followed the men to the door, was the first to smother the young girl in hugs and kisses, and an ample dose of tears with the others joining in with equal enthusiasm.
Fifteen grains constitute an exceedingly dangerous dose for an adult male of average weight.
The official dose of powdered colchicum is 2 to 5 grains, which may be given in a cachet.
They contain a volatile oil which does not occur in the corm, and their proportion of colchicine is higher, for which reason the Tinctura Colchici Seminum- dose 5 to 15 minims - is preferable to the wine prepared from the corm.
Of the two latter, 300 grains may be given in a dose and i 2 oz.
(2) Plumbi Acetas (sugar of lead), dose 1 to 5 grains.
==Toxicology== In a few minutes after the introduction of a poisonous dose of aconite, marked symptoms supervene.
The dose for repeated administration is from 10 to 30 minims and for a single administration up to a drachm.
A dose of a little more than a drachm (a teaspoonful) will produce a condition of inebriation lasting for one-half to one hour, but the dose must soon be greatly increased.
Pomegranate root, or, better, the sulphate of pelletierine in dose of 5 grains with an equal quantity of tannic acid, may be used to replace the male fern.
The dose of jalap is from five to twenty grains, the British Pharmacopeia directing that it must contain from 9 to II% of the resin, which is given in doses of two to five grains.
The dose is from 20 grains to a drachm.
It is best given in the maximum dose which causes the minimum of irritation.
The dose is 2 to 5 grains, that of aloin being z to 2 grains.
The dose of the fruit is 30 to 60 grains, and the British Pharmacopoeia contains a tincture with a dose of a to 1 drachm.
It is best to begin with only one dose in the twenty-four hours, to be taken just before going to sleep, so that the patient is saved its unpleasant "repetition" from an unaccustomed stomach.
In general, it is therefore wise to order a double dose at bedtime.
The usual dose, at starting, is one or two drachms, but the oil should be given eventually in the largest quantities that the patient can tolerate.
Once acquired the habitué depends on the drug for a comfortable existence, and as the organism becomes quickly tolerant of the alkaloid the original dose no longer suffices.
The B.P. preparation Liquor Hydrogenii Peroxidi dose i to 2 drs.
A toxic dose causes unpleasant symptoms, but in certain cases, such as this, it may require very many times a toxic dose to produce the lethal effect.
There are numerous preparations, patent and pharmacopeial, their composition being extremely varied, so that, unless one has reason to be certain of any particular preparation, it is almost better to use only the dried leaves themselves in the form of a powder (dose a-z grains).
The pharmacopeial tincture may be given in doses of five to fifteen minims, and the infusion has the unusually small dose of two to four drachms - the dose of other infusions being an ounce or more.
The dose is from a drachm to an ounce.
The B.P. dose of strychnine is to gr.
The average fatal dose for an adult is i 2 grs., but death has resulted in twenty minutes from 2 grain.
A similar stimulation of the non-striped muscle in the alimentary canal results in violent vomiting and purging, if a large dose has been taken.
The respiration is at first accelerated by a dose of physostigmine, but is afterwards slowed and ultimately arrested.
Thus atropine will save life after three and a half times the fatal dose of physostigmine has been taken, but will hasten the end if four or more times the fatal dose has been ingested.