In the country of Versace, Ferragamo, Lamborghini, the Colosseum, and Michelangelo, that alone is quite a distinction.
Do some research on the Colosseum before you go, it will make the experience much more enjoyable.
Some of the more famous sites, such as the Colosseum or the Vatican Museum, are popular for a very good reason.
You can also pick up an audio guide inside the Colosseum, or just wander near other tour groups and listen in to pieces of their speech.
To skip the long lines into the arena, see Palatine Hill first, then stroll down to the Colosseum.
Here you'll find the Colosseum, the Forum Romanum (Forum), Palatine Hill and much, much more.
It is inferior in size only to the Colosseum and the amphitheatres of Capua and Verona, measuring about 153 by 130 yds.
It stretched from the Palatine across the low ground, afterwards occupied by the Colosseum, to the Esquiline.
The most conspicuous of them is the great amphitheatre, a building perhaps of the end of the 1st century A.D., which in general form closely resembled the Colosseum in Rome.
Much money was spent on public works and the restoration and beautifying of Rome - a new forum, the splendid temple of Peace, the public baths and the vast Colosseum being begun under Vespasian.