Silicon chloroform, SiHC1 3, first prepared by H.
Chloroform may be given internally in doses of from one to five drops.
It is soluble in alcohol, ether, chloroform and boiling water.
We may here mention the synthesis of oxyuvitic ester (5-methyl-4-oxy-I-3-benzene dicarboxylic ester) by the condensation of two molecules of sodium acetoacetic ester with one of chloroform (Ann., 1883, 222, p. 249).
Which with baryta gave chloroform and maleic acid.
The heptachlor compound when treated with chlorine water gives trichloraceto-pentachlorbutyric acid (6), which is hydrolysed by alkalis to chloroform and pentachlorglutaric acid (7), and is converted by boiling water into tetrachlor-diketo-Rpentene (8).
This latter compound may be chlorinated to perchloracetoacrylic chloride (9), from which the corresponding acid (to) is obtained by treatment with water; alkalis hydrolyse the acid to chloroform and dichlormaleic acid (I I).
Pyrrol is readily converted into pyridine derivatives by acting with bromoform, chloroform, or methylene iodide on its potassium salt, t3-brom-and O-chlorpyridine being obtained with the first two compounds, and pyridine itself with the last.
If ozone is passed into a solution of rubber in chloroform the caoutchouc combines with a molecule of ozone forming a compound of the empirical composition C 5 H 8 O 8.
This should be painted on the affected part with a camel's hair brush dipped in chloroform, which facilitates the absorption of the alkaloid.
Over and above the bacterial intoxications we have a very extreme degree of fatty degeneration, widely distributed throughout the tissues, which is produced by certain organic and inorganic poisons; it is seen especially in phosphorus and chloroform poisoning.
Formic acid yields acridine, and the higher homologues give derivatives substituted at the meso carbon atom, N N +[[Hcooh-C 6 H 5 /Inc6h5->C6h4 C6h4 Cho Ch N N +Ch 3 000h->C 6 H 5 /IC 6 H 5 --C 6 H 4 < >C6h4 Coch 3 C]](CH3) Acridine may also 1:e obtained by passing the vapour of phenylortho-toluidine through a red-hot tube (C. Graebe, Ber., 1884, 17, p. 1 37 0); by condensing diphenylamine with chloroform, in presence of aluminium chloride (0.
Ruff and Curt Albert (Ber., 1905, 38, p. 53) by decomposing titanium fluoride with silicon chloroform in sealed vessels at 100 -120° C. It is a colourless gas which may be condensed to a liquid boiling at -80 2° C. On solidification it melts at about -110° C. The gas is very unstable, decomposing slowly, even at ordinary temperatures, into hydrogen,, silicon fluoride and silicon: 4SiHF 3 =2H 2 +3SiF 4 +Si.
Silicon nitrogen hydride, SiNH, is a white powder formed with silicon amide when ammonia gas (diluted with hydrogen) is brought into contact with the vapour of silicon chloroform at -10° C. Trianilino silicon hydride, SiH (NHC 6 H 5) 3, is obtained by the action of aniline on a benzene solution of silicon chloroform.
It is a monacid base; the hydrochloride, C 20 H 17 N0 4 HC1, is insoluble in cold alcohol, ether and chloroform, and soluble in 500 parts of water; the acid sulphate, C 20 H 17 N0 4 H 2 SO 4, dissolves in about loo parts of water.
It is only very sparingly soluble in water, but dissolves readily in solutions of the alkaline iodides and in alcohol, ether, carbon bisulphide, chloroform, and many liquid hydrocarbons.
Its solutions in the alkaline iodides and in alcohol and ether are brown in colour, whilst in chloroform and carbon bisulphide the solution is violet.
By acting with ozone on a chloroform solution of iodine, F.
It is obtained by passing ammonia gas over hot coal; by subliming a mixture of ammonium chloride and potassium cyanide; by passing a mixture of ammonia gas and chloroform vapour through a red hot tube; and by heating a mixture of ammonia and carbon monoxide: CO+2NH 3 = NH 4 NC+H 2 0.
Chloroform may be readily detected by the production of an isonitrile when it is heated with alcoholic potash and a primary amine; thus with aniline, phenyl isocyanide (recognized by its nauseating smell) is produced, CHC13+C6H5NH2+3KHO=C6H5NC+3KC1+3H20.
For the action and use of chloroform as an anaesthetic, see Anaesthesia.
The British Pharmacopoeia contains a watery solution - the Aqua Chloroformi - which is useful in disguising the taste of nauseous drugs; a liniment which consists of equal parts of camphor liniment and chloroform, and is a useful counter-irritant; the Spiritus Chloroformi (erroneously known as "chloric ether"), which is a useful anodyne in doses of from five to forty drops; and the Tinctura Chloroformi et Morphinae Composita, which is the equivalent of a proprietary drug called chlorodyne.
This tincture contains chloroform, morphine and prussic acid, and must be used with the greatest care.
The uses of chloroform which fall to be mentioned here are: - as a counter-irritant; as a local anaesthetic for toothache due to caries, it being applied on a cotton wool plug which is inserted into the carious cavity; as an antispasmodic in tetanus and hydrophobia; and as the best and most immediate and effective antidote in cases of strychnine poisoning.
It forms colourless needles which melt at 94° C.; and is readily soluble in alcohol, ether, chloroform, and caustic alkalis.
It is readily soluble in water and in alcohol, but is insoluble in chloroform and ether.
Oxygen is also administered in chloroform poisoning, and in threatened death from the inhalation of coal gas or nitrous oxides.
It exists in two crystalline forms. Nitric acid passed into its chloroform solution gives phenyl diazonium nitrate.
It is obtained by condensing benzal chloride with mercury diphenyl (Kekule and Franchimont, Ber., 1872, 5, p. 907); from benzal chloride or benzotrichloride and zinc dust or aluminium chloride; from chloroform or carbon tetrachloride and benzene in the presence of aluminium chloride; and deamidating diand tri-aminotriphenylmethane with nitrous acid and alcohol (0.
It has been used by some surgeons for the production of anaesthesia previous to the administration of ether or chloroform, but the use of the method is now more usually relegated to obstetric practice.
It is readily soluble in hydrocarbon solvents, in chloroform and in alcohol.
In chloroform solution it combines with anhydrous oxalic acid to form a compound, Sb2C18(C204), which is to be considered as COOSbC14 tetra-chlorstibonium oxalate I (R.
CHLOROFORM (trichlor-methane), CHC1 3, a valuable anaesthetic, a colourless liquid, possessing an agreeable smell and a pleasant taste.
In the preparation of chloroform by the action of bleaching powder on ethyl alcohol it is probable that the alcohol is ..rst oxidized to acetaldehyde, which is subsequently chlorinated and then decomposed.
Chloroform solidifies in the cold and then melts at - 62° C.; it boils at 61.2° C., and has a specific gravity I.
The vapour of chloroform when passed through a red-hot tube yields hexachlorbenzene C 6 C1 6, perchlorethane C,C1 6, and some perchlorethylene C 2 C1 4 (W.
In ccllapse following severe haemorrhage and in sudden and accidental arrest of the heart or respiration during chloroform narcosis an intramuscular injection of 1 gr.
The treatment of strychnine poisoning is to immediately evacuate the stomach with a stomach-pump or emetic, chloroform being administered to allay the spasms. If the patient can swallow, draughts of water containing tannic acid may be given.
In the meanwhile relief may be afforded by fomentations, and by morphia or chloroform, but if no prospect of the stone escaping into the intestine appears likely, the surgeon will be called upon to remove it by an incision through the gall-bladder, or the bile-duct, or through the intestine at the spot where it is trying to make its escape.
Chloroform boiled with alcoholic potash forms potassium formate (J.
The solubility of the gas in various liquids, as given by different observers, is zoo Volumes of Brine Water Alcohol Paraffin Carbon disulphide Fusel oil Benzene Chloroform Acetic acid Acetone It will be seen from this table that where it is desired to collect and keep acetylene over a liquid, brine, i.e.
Primary amines when heated with alcoholic potash and chloroform yield isonitriles, which are readily detected by their offensive smell.