The attempts of Methodius of Tyre at the beginning of the 4th century and Apollinarius of Laodicea about 360 to defend chiliasm and assail the theology of Origen had no result.
The teaching of Apollinarius that in Christ the Divine Word took the place of the human rational soul, thus seeming to do away with his possession of a true humanity, had led to a reaction by Paul of Samosata, Diodore of Tarsus, Theodore of Mopsuestia, and Nestorius of Constantinople.
From the days of Ignatius, down through Paul of Samosata and Lucian to the 'great controversies of the 5th century which began with the theories of Apollinarius, the theologians of Antioch started from the one sure fact, that 1 Coptic Life of Dioscurus (Rev. Egyptologique, 1880-1883).
So Apollinaris or Apollinarius of Laodicea taught, but the Council of Constantinople (381) marked the position as heretical.