Soon after Antiochus's accession, Media and Persis revolted under their governors, the brothers Molon and Alexander.
Confronted Antiochus at Raphia and inflicted a defeat upon him which nullified all Antiochus's successes and compelled him to withdraw north of the Lebanon.
After sustaining a famous siege in his capital Bactra (Balkh), Euthydemus obtained an honourable peace by which the hand of one of Antiochus's daughters was promised to his son Demetrius.
Antiochus's attempt to suppress the religion of the Jews (i Macc. i.
Was dead and his sister Berenice had been murdered, together with her infant son, by Antiochus's former wife, Laodice, who claimed the kingdom for her son Seleucus II.