The mainstay of treatment for FMF is an oral medication called colchicine, which is highly effective for the fever and pain that accompany the disorder, as well as for amyloidosis and the kidney disease that can result from it.
The frequency of amyloidosis varies among the different ethnic groups, and its overall incidence is difficult to determine because of the use of colchicine to avert the problem.
Unexplained recurrent fevers, polyserositis, skin rash, and/or joint pain; abnormal blood studies (see below); and kidney or other disease associated with amyloidosis.
Secondary amyloidosis occurs in patients suffering from chronic infections or inflammatory diseases such as tuberculosis, rheumatoid arthritis, and Crohn's disease.
Amyloidosis is a potentially serious condition in which proteins called amyloids are mistakenly produced and deposited in organs and tissues throughout the body.
Amyloidosis may affect the gastrointestinal tract, liver, spleen, heart, and (in males) testes, but its effects on the kidneys are of greatest concern.
Left untreated, however, those individuals who do develop amyloidosis of the kidneys may require a kidney transplant or may even die of renal failure.
The frequency and severity of a person's attacks of fever and serositis seem to have no relation to the risk of developing amyloidosis.
Most will have very few, if any, attacks of fever and polyserositis and will likely not develop serious complications of amyloidosis.
Hft.); Nowak, " Experimental Researches on Amyloidosis," Arch.