" Amyloid " occurs as a pathological product, and also in the healthy aorta and in old cartilage.
Some organs are subject to enlargement from deposition within them of a foreign substance (amyloid, fat, &c.).
The hyaline material, unlike the amyloid, does not give the metachromatic staining reactions with methyleneviolet or iodine.
The wax-like or amyloid substance has a certain resemblance to the colloid, mucoid and hyaline.
The name "amyloid " was applied to it by Virchow on account of the blue reaction which it gives occasionally with iodine and sulphuric acid, resembling that given with vegetable cellulose.
Oddi in 1894 isolated from the amyloid liver a substance which Schmiedeberg had previously obtained from cartilage and named " chondroitinic-sulphuric acid " (Chondroitinschwefelsaure).
Oddi does not regard it as the essential constituent of amyloid, chiefly because the colour reactions are forthcoming in the residuum after the substance has been removed, while the substance itself does not give these reactions.
Quite likely the amyloid may be a combination of the substance with a proteid.
This amyloid substance is slowly and imperfectly digested by pepsin - digestion being more complete with trypsin and by autolytic enzymes.
Amyloid develops in various organs and tissues and is commonly associated with chronic phthisis, tubercular disease of bone and joints, and syphilis (congenital and acquired).
A number of interesting experiments, designed to test the relationship between the condition of suppuration and the production of amyloid, have been made of late years.
When hardened in spirit, however, the greater part of this experimental amyloid in the fowl vanishes, and the reactions are not forthcoming.
It further resembles true amyloid in giving all its colour reactions.
The reaction with methylviolet, however, differs from that with true amyloid in being evanescent.
201; Davidsohn, " Experimental Amyloid," Arch.
450; Krawkow, " Chemistry of Amyloid," Arch.
195, also " Experimental Amyloid," Arch.
172; Lubarsch, " Experimental Amyloid," Arch.
162; Oddi, " Nature of Amyloid," Arch.